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View a compilation of Hemanext publications from a wide variety of studies, abstracts, and posters that are categorized by various aspects of blood quality. Also explore other publications in related field of research.

Current Thinking on Blood Quality

Ours:

  1. Yoshida T, Prudent M, D’Alessandro A. Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus 2019; 17: 27-52.
  2. Reisz JA, Nemkov T, Dzieciatkowska M, et al. Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells. Transfusion 2018; 58 (12): 2978-2991.
  3. Reisz JA, Wither MJ, Dzieciatkowska M, et al. Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. Blood 2016; 128 (12): e32-42.
  4. Yoshida T, Blair A, Keegan P, et al. Heterogeneity in blood oxygen saturation as an underappreciated driver of variance in red blood cell quality. Transfusion 2016; 56 (S4): 61A. [Meeting Abstract]

Others:

  1. Jones AR, Patel RP, Marques MB, et al. Older Blood Is Associated With Increased Mortality and Adverse Events in Massively Transfused Trauma Patients: Secondary Analysis of the PROPPR Trial. Ann Emerg Med 2019; 73 (6): 650-661.
  2. Glynn SA, Klein HG, Ness PM. The red blood cell storage lesion: the end of the beginning. Transfusion 2016; 56 (6): 1462-8.
  3. Zimring JC. Established and theoretical factors to consider in assessing the red cell storage lesion. Blood 2015; 125 (14): 2185-2190.
Pathogen Inactivation
Red Blood Cell Quality and Hypoxic Storage

Ours:

  1. DʼAlessandro A, Yoshida T, Nestheide S, et al. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion 2020; 60 (4): 786-798.
  2. DePew S, Marques M, Patel R, et al. Estimating Oxidative Stress Burden of Multiple Blood Transfusions in Trauma Patients. Transfusion 2020; 60 (S5): 40A. [Meeting Abstract]
  3. Karafin M, Shevkoplyas S, Charles-Delva M, et al. Hypoxic Storage of Donor Red Cells Improves Deformability after Exposure to Plasma from Adults with Sickle Cell Disease during Vaso-Occlusive Crisis. Transfusion 2020; 60 (S5): P-BB-32. [Meeting Abstract]
  4. Coker S, Ceniza M, Charles-Dleva M, et al. Hypoxic Storage in Novel Non-DEHP Bags Improves Red Blood Cell Quality during 56 Day Storage at 4°C. Transfusion 2020; 60 (S5): 183A. [Meeting Abstract]
  5. Whitley P, Wellington S, Howard P, et al. Improved Quality of CP2D/AS-3 Red Blood Cells Processed and Stored for 42 days in the Hemanext Oxygen Reduction System After X-Ray Irradiation at Day 14 or Day 21. Transfusion 2020; 60 (S5): 184A. [Meeting Abstract]
  6. Williams AT, Jani VP, Nemkov T, et al. Transfusion of Anaerobically or Conventionally Stored Blood After Hemorrhagic Shock. Shock 2020; 53 (3): 352–362.
  7. Sowemimo-Coker SO, Kuypers F, Larkin S, et al. Effects of Hypoxic Red Blood Cells on Sickling Kinetics of Red Blood Cells from Patients with Sickle Cell Disease. 2019 October; 59 (S3): 157A. [Meeting Abstract]
  8. Sowemimo-Coker SO, Ceniza M, Delva-Charles ML, et al. Hypoxic Storage Improves Viscoelastic Properties and Reduces Methemoglobin Formation in Gamma Irradiated Red Blood Cells. Transfusion 2019; 59 (S3): 156A. [Meeting Abstract]
  9. D’Alessandro A, Nemkov T, Stefanoni D, et al. Metabolic Predictors of 24h Post-Transfusion Recovery in End of Storage Control and Hypoxic Red Blood Cells. Transfusion 2019; 59 (S3): 16A. [Meeting Abstract]
  10. Yoshida T, Rugg N, Whitley PH, et al. In Vitro RBC Deformability is a Predictor of Long-Term Stored RBC PTR24 In Vivo while ATP is a Predictor of RBC PTR24 in Hypoxic Stored RBC. Transfusion 2019; 59 (S3): 63A. [Meeting Abstract]
  11. Nemkov T, Sun K, Reisz JA, et al. Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage. Haematologica 2018; 103 (2): 361–372.
  12. Prudent M, Martin A, Abonnenc M, et al. Oxygen in Red Blood Cell Concentrate: Influence of Donor’s Characteristics, Location and Blood Processing. Vox Sang 2018; 113: 116. [Meeting Abstract]
  13. Korsten H, Yoshida T, de Korte D. Determination of %SO2 in More Than 1300 Fresh Erythrocyte Concentrates by Resonance Raman Spectroscopy. Transfusion 2018; 58 (S2): 215A. [Meeting Abstract]
  14. Nemkov T, Sun K, Reisz JA, et al. Metabolism of Citrate and Other Carboxylic Acids in Erythrocytes As a Function of Oxygen Saturation and Refrigerated Storage. Front Med (Lausanne) 2017; 4: 175.
  15. Fast L, Coker S, Dunham A. Effects of Gamma Irradiation on the Growth of T-Lymphocytes and Quality of Red Blood Cells Stored in Oxygen-Reduced Condition. Transfusion 2018; 58 (S2):151A. [Meeting Abstract]
  16. Yoshida T, Blair A, D’Alessandro A, Nemkov T, et al. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Transfusion 2017; 15: 172-81.
  17. Yoshida T, Nemkov T, Blair A, et al. Unexpected Variability of Hemoglobin Oxygen Saturation in Packed Red Blood Cells upon Donation Suggests Uncontrolled and Overlooked Parameter Associated with the Development of the Storage Lesion. Transfusion 2017; 57: 3A-264A. [Meeting Abstract]
  18. Yoshida T, Blair A, Cheves T, et al. Oxygen content–uncontrolled and overlooked parameter associated with stored red cell concentrate: Unexpectedly wide distribution. Vox Sang 2017; 112: 5-295. [Meeting Abstract]
  19. D’Alessandro A, Nemkov T, Blair A, et al. Anaerobic storage condition enhances GSH levels while maintaining pentose phosphate pathway activity. Transfusion 2016; 56 (S4): 51A. [Meeting Abstract]
  20. Piety NZ, Stutz J, Yilmaz HD, et al. Anaerobic conditions reduce deterioration of rheological properties of stored red blood cells. Transfusion 2016; 56 (S4): 24A. [Meeting Abstract]
  21. Dumont LJ, D’Alessandro A, Szczepiorkowski ZM, et al. CO2 -dependent metabolic modulation in red blood cells stored under anaerobic conditions. Transfusion 2016; 56 (2): 392-403.
  22. Burns JM, Yoshida T, Dumont LJ, et al. Deterioration of red blood cell mechanical properties is reduced in anaerobic storage. Blood Transfus 2016; 14 (1): 80-8.
  23. Van Buskirk C, Karon B, Emery R, et al. Comparison of Cytokine, Cell-free Hemoglobin, and Isoprostane Accumulations in Packed Red Blood Cells During Novel Anaerobic and Conventional Cold Storage. Transfusion 2014; 54: 74A. [Meeting Abstract]
  24. Van Buskirk C, Tarara J, Jy W, et al. Comparison of microparticles production in packed red blood cells stored under anaerobic and conventional cold storage condition. Vox Sanguinis 2013; 105 (S1): 150. [Meeting Abstract]
  25. Yoshida T, Vernucci P, Vassallo RR, et al. Reduction of microparticle generation during anaerobic storage of red blood cells. Transfusion 2012; 52 (S3): 83A. [Meeting Abstract]
  26. Burns J, Yang X, Yoshida T, et al. Anaerobic storage improves the mechanical properties of stored red blood cells. Transfusion 2012; 52: 83A. [Meeting Abstract]
  27. Dumont L, Szczepiorkowski Z, Siegel A, et al. Randomized cross-over in vitro and in vivo evaluation of a prototype anaerobic conditioning and storage system vs. standard aerobic storage. Vox Sanguinis 2012; 103 (S1): 123.
  28. Jy W, Bidot CJ, Yoshida T, et al. Release of Microparticles During Blood Storage Is Influenced by Residual Platelets, Leukocytes and Oxygen Levels. Blood 2012; 120: 3435. [Meeting Abstract]
  29. Dumont LJ, Szczepiorkowski Z, Siegel A, et al. Performance of anaerobic stored red blood cells prepared using a prototype O2 & CO2 depletion and storage system. Transfusion 2011; 51S: 77A. [Meeting Abstract]
  30. Yoshida T, Shevkoplyas SS. Anaerobic storage of red blood cells. Blood Transfus 2010; 8 (4): 220-36.
  31. Dumont LJ, Baker S, Calcagni KE, et al. CO2 effects during anaerobic storage of RBC. Transfusion 2010; 50: 9A. [Meeting Abstract]
  32. Yoshida T, AuBuchon JP, Tryzelaar L, et al. Extended storage of red blood cells under anaerobic conditions. Vox Sang 2007; 92 (1): 22-31.
  33. Yoshida T, Lee J, McDonough W, et al. Anaerobic storage of red blood cells for 9 weeks: in vivo and in vitro characteristics. Transfusion 1997; 37S(104S). [Meeting Abstract]

Others:

  1. D’Alessandro A, Travis N, Hill RC. Red blood cell metabolic responses during blood bank storage under mild and acute hypoxia. Vox Sanguinis 2016; 111 (S1): 7-305. [Meeting Abstract]
Whole Blood and Hypoxic Storage
  1. Camille Van Buskirk, Nga Thai, Ranee Wannarka, et al. Measurement of Platelet Function and Select Cytokines of Whole Blood Stored in Novel Hypoxic Platform. Transfusion 2019; 59 (S3): 160A. [Meeting Abstract]
  2. Van Buskirk CM, Thai NB, Emery RL, et al. Evaluation of select red blood cell biochemical and coagulation properties in whole blood stored using a novel anaerobic storage platform. Transfusion 2016; 56 (S4): 54A. [Meeting Abstract]
Hemanext Device
  1. Dunham A, Yoshida T, Cordero R, et al. Hemanext: device and method for establishing and maintaining controlled oxygen environment for storage of red blood cells. Vox Sanguinis 2016; 111 (S1): 53. [Meeting Abstract]
Microfluidics for Blood Characterization
  1. Shevkoplyas SS, Yoshida T, Gifford SC, et al. Direct measurement of the impact of impaired erythrocyte deformability on microvascular network perfusion in a microfluidic device. Lab on a chip 2006; 6 (7): 914-20.
  2. Shevkoplyas SS, Yoshida T, Munn L, et al. Biomimetic autoseparation of leukocytes from whole blood in a microfluidic device. Analytical chemistry 2005; 77 (3): 933-7.
  3. Shevkoplyas SS, Gifford SC, Yoshida T, et al. Prototype of an in vitro model of the microcirculation. Microvascular Research 2003; 65 (2): 132-6.
  4. Gifford SC, Frank MG, Derganc J, et al. Parallel microchannel-based measurements of individual erythrocyte areas and volumes. Biophysical Journal 2003; 84 (1): 623-33.
Red Blood Cell Storage in Additive Solution
  1. Tan JCG, Aung HH, Cha Y, et al. Additive Solutions Differentially Influence the Effects of Hypoxic Storage on Red Blood Cell In Vitro Quality. Transfusion 2019; 59 (S3): 58A. [Meeting Abstract]
  2. D’Alessandro A, Nemkov T, Yoshida T, et al. Citrate metabolism in red blood cells stored in additive solution-3. Transfusion 2017; 57 (2): 325-36.
  3. D’Amici GM, Mirasole C, D’Alessandro A, et al. Red blood cell storage in SAGM and AS3: a comparison through the membrane two-dimensional electrophoresis proteome. Blood Transfusion 2012; 10 (S2): s46-54.
  4. Dumont LJ, Yoshida T, AuBuchon JP. Anaerobic storage of red blood cells in a novel additive solution improves in vivo recovery. Transfusion 2009; 49 (3): 458-64.
  5. Yoshida T, AuBuchon JP, Dumont LJ, et al. The effects of additive solution pH and metabolic rejuvenation on anaerobic storage of red cells. Transfusion 2008; 48 (10): 2096-105.
  6. Yoshida T, Bitensky M, Tryzelaar L, et al. Effect of oxygen removal on 9-week storage of red blood cells in EAS61 additive solution. Transfusion 2000; 40S: 56S. [Meeting Abstract]
  7. Yoshida T, Bitensky M, Pickard C, et al. 9-week storage of red blood cells in AS3 under oxygen depleted conditions. Transfusion 1999; 39S: 109S. [Meeting Abstract]
Further Reading on Red Blood Cell Characterization
  1. Yoshida T, Whitley PH, Rugg N, et al. Oxygen Saturation of Collected RBC Products is Donor Dependent. Transfusion 2019; 59 (S3): 63A. [Meeting Abstract]
  2. Lin HW, Rundek T, Yoshida T. Letter by Lin et al regarding article, “Nitric oxide scavenging of red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.” Circulation 2012; 125 (7): e384.
  3. Gifford SC, Derganc J, Shevkoplyas SS, et al. A detailed study of time-dependent changes in human red blood cells: from reticulocyte maturation to erythrocyte senescence. British Journal of Haematology 2006; 135 (3): 395-404.
  4. Gifford SC, Yoshida T, Shevkoplyas SS, et al. A high-resolution, double-labeling method for the study of in vivo red blood cell aging. Transfusion 2006; 46 (4): 578-88.
  5. Yoshida T, Dembo M. A thermodynamic model of hemoglobin suitable for physiological applications. The American Journal of Physiology 1990; 258 (3 Pt 1): C563-77.
  6. Yoshida T, Dembo M. Toward a comprehensive biochemical model of human erythrocyte: relationship between metabolic and osmotic state of the cell and the state of hemoglobin. Progress in Clinical and Biological Research 1989; 319: 179-93; discussion 194-6.
Abstracts
AABB
  1. Coker S, Ceniza M, Charles-Dleva M, et al. Hypoxic Storage in Novel Non-DEHP Bags Improves Red Blood Cell Quality during 56 Day Storage at 4°C. Transfusion 2020; 60 (S5): 183A. [Meeting Abstract]
  2. DePew S, Marques M, Patel R, et al. Estimating Oxidative Stress Burden of Multiple Blood Transfusions in Trauma Patients. Transfusion 2020; 60 (S5): 40A. [Meeting Abstract]
  3. Karafin M, Shevkoplyas S, Charles-Delva M, et al. Hypoxic Storage of Donor Red Cells Improves Deformability after Exposure to Plasma from Adults with Sickle Cell Disease during Vaso-Occlusive Crisis. Transfusion 2020; 60 (S5): P-BB-32. [Meeting Abstract]
  4. Whitley P, Wellington S, Howard P, et al. Improved Quality of CP2D/AS-3 Red Blood Cells Processed and Stored for 42 days in the Hemanext Oxygen Reduction System After X-Ray Irradiation at Day 14 or Day 21. Transfusion 2020; 60 (S5): 184A. [Meeting Abstract]
  5. Camille Van Buskirk, Nga Thai, Ranee Wannarka, et al. Measurement of Platelet Function and Select Cytokines of Whole Blood Stored in Novel Hypoxic Platform. Transfusion 2019; 59 (S3): 160A. [Meeting Abstract]
  6. D’Alessandro A, Nemkov T, Stefanoni D, et al. Metabolic Predictors of 24h Post-Transfusion Recovery in End of Storage Control and Hypoxic Red Blood Cells. Transfusion 2019; 59 (S3): 16A. [Meeting Abstract]
  7. Sowemimo-Coker SO, Ceniza M, Delva-Charles ML, et al. Hypoxic Storage Improves Viscoelastic Properties and Reduces Methemoglobin Formation in Gamma Irradiated Red Blood Cells. Transfusion 2019; 59 (S3): 156A. [Meeting Abstract]
  8. Sowemimo-Coker SO, Kuypers F, Larkin S, et al. Effects of Hypoxic Red Blood Cells on Sickling Kinetics of Red Blood Cells from Patients with Sickle Cell Disease. Transfusion 2019; 59 (S3): 157A. [Meeting Abstract]
  9. Tan JCG, Aung HH, Cha Y, et al. Additive Solutions Differentially Influence the Effects of Hypoxic Storage on Red Blood Cell In Vitro Quality. Transfusion 2019; 59 (S3): 58A. [Meeting Abstract]
  10. Van Buskirk C, Thai N, Farlinger RW, et al. Measurement of Platelet Function and Select Cytokines of Whole Blood Stored in Novel Hypoxic Platform. Transfusion 2019; 59 (S3): 160A.
  11. Yoshida T, Rugg N, Whitley PH, et al. In Vitro RBC Deformability is a Predictor of Long-Term Stored RBC PTR24 In Vivo while ATP is a Predictor of RBC PTR24 in Hypoxic Stored RBC. Transfusion 2019; 59 (S3): 63A. [Meeting Abstract]
  12. Yoshida T, Whitley PH, Rugg N, et al. Oxygen Saturation of Collected RBC Products is Donor Dependent. Transfusion 2019; 59 (S3): 63A. [Meeting Abstract]
  13. Fast L, Coker S, Dunham A. Effects of Gamma Irradiation on the Growth of T-Lymphocytes and Quality of Red Blood Cells Stored in Oxygen-Reduced Condition. Transfusion 2018; 58 (S2):151A. [Meeting Abstract]
  14. Korsten H, Yoshida T, de Korte D. Determination of %SO2 in More Than 1300 Fresh Erythrocyte Concentrates by Resonance Raman Spectroscopy. Transfusion 2018; 58 (S2): 215A. [Meeting Abstract]
  15. Yoshida T, Nemkov T, Blair A, et al. Unexpected Variability of Hemoglobin Oxygen Saturation in Packed Red Blood Cells upon Donation Suggests Uncontrolled and Overlooked Parameter Associated with the Development of the Storage Lesion. Transfusion 2017; 57: 3A-264A. [Meeting Abstract]
  16. D’Alessandro A, Nemkov T, Blair A, et al. Anaerobic storage condition enhances GSH levels while maintaining pentose phosphate pathway activity. Transfusion 2016; 56 (S4): 51A. [Meeting Abstract]
  17. Piety NZ, Stutz J, Yilmaz HD, et al. Anaerobic conditions reduce deterioration of rheological properties of stored red blood cells. Transfusion 2016; 56 (S4): 24A. [Meeting Abstract]
  18. Van Buskirk CM, Thai NB, Emery RL, et al. Evaluation of select red blood cell biochemical and coagulation properties in whole blood stored using a novel anaerobic storage platform. Transfusion 2016; 56 (S4): 54A. [Meeting Abstract]
  19. Yoshida T, Blair A, Keegan P, et al. Heterogeneity in blood oxygen saturation as an underappreciated driver of variance in red blood cell quality. Transfusion 2016; 56 (S4): 61A. [Meeting Abstract]
  20. Van Buskirk C, Karon B, Emery R, et al. Comparison of Cytokine, Cell-free Hemoglobin, and Isoprostane Accumulations in Packed Red Blood Cells During Novel Anaerobic and Conventional Cold Storage. Transfusion 2014; 54: 74A. [Meeting Abstract]
  21. Burns J, Yang X, Yoshida T, et al. Anaerobic storage improves the mechanical properties of stored red blood cells. Transfusion 2012; 52: 83A. [Meeting Abstract]
  22. Yoshida T, Vernucci P, Vassallo RR, et al. Reduction of microparticle generation during anaerobic storage of red blood cells. Transfusion 2012; 52 (S3): 83A. [Meeting Abstract]
  23. Dumont LJ, Szczepiorkowski Z, Siegel A, et al. Performance of anaerobic stored red blood cells prepared using a prototype O2 & CO2 depletion and storage system. Transfusion 2011; 51S: 77A. [Meeting Abstract]
  24. Dumont LJ, Baker S, Calcagni KE, et al. CO2 effects during anaerobic storage of RBC. Transfusion 2010; 50: 9A. [Meeting Abstract]
  25. Yoshida T, Lee J, McDonough W, et al. Anaerobic storage of red blood cells for 9 weeks: in vivo and in vitro characteristics. Transfusion 1997; 37S(104S). [Meeting Abstract]

ISBT

  1. Prudent M, Martin A, Abonnenc M, et al. Oxygen in Red Blood Cell Concentrate: Influence of Donor’s Characteristics, Location and Blood Processing. Vox Sang 2018; 113: 116. [Meeting Abstract]
  2. Yoshida T, Blair A, Cheves T, et al. Oxygen content–uncontrolled and overlooked parameter associated with stored red cell concentrate: Unexpectedly wide distribution. Vox Sang 2017; 112: 5-295. [Meeting Abstract]
  3. Van Buskirk C, Tarara J, Jy W, et al. Comparison of microparticles production in packed red blood cells stored under anaerobic and conventional cold storage condition. Vox Sanguinis 2013; 105 (S1): 150. [Meeting Abstract]
  4. Dumont L, Szczepiorkowski Z, Siegel A, et al. Randomized cross-over in vitro and in vivo evaluation of a prototype anaerobic conditioning and storage system vs. standard aerobic storage. Vox Sanguinis 2012; 103 (S1): 123.

ASH

  1. Cancelas JA, West FB, Karaffin M, et al. Long-Term Hypoxic/Hypocapnic Storage of Red Blood Cells Results in Amelioration of Lesion Hallmarks and Increased In Vivo recovery at 24 Hours Post-Transfusion. Blood 2019; 134 (S1): 4995. [Meeting Abstract]
  2. Jy W, Bidot CJ, Yoshida T, et al. Release of Microparticles During Blood Storage Is Influenced by Residual Platelets, Leukocytes and Oxygen Levels. Blood 2012; 120: 3435. [Meeting Abstract]

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