Our Science

Our Science

Strong foundational science has proven that oxygen has detrimental effects on red blood cells (RBCs) during storage1-6 Excess oxygen contributes to RBC degradation, leading to development of the storage lesion – the collection of metabolic, oxidative, and structural changes to RBCs that affect their quality, functionality, and viability.1,2,7

Our technology uses a proprietary sorbent layer to remove excess oxygen from RBCs during processing and then to preserve them in a hypoxic state using an impermeable storage bag.8 This method consistently protects the high-quality RBCs throughout the entire storage period.9,10

See how conventional RBC processing and storage can be improved by applying Our Science.

Stored RBCs

Oxygen causes detrimental effects on RBCs during storage.
 
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Storage Lesion

The storage lesion refers to the collection of changes that occur to RBCs during storage.
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Hypoxic Storage

Hypoxic storage has been proven to mitigate the RBC storage lesion by limiting the effects of oxygen.
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[1] Yoshida T, Prudent M, D’Alessandro A. Red blood cell storage lesion: causes and potential clinical consequences. Blood Transfus. 2019;17(1):27-52. [2] Yoshida T, Shevkoplyas SS. Anaerobic storage of red blood cells. Blood Transfus. 2010;8(4):220-36. [3] Rabcuka J, Blonski S, Meli A, et al. Metabolic reprograming under hypoxic storage preserves faster oxygen unloading from stored red blood cells. Blood Adv. 2022; 6(18):5415-5428. doi: 10.1182/bloodadvances.2022007774. [4] Orlov D and Karkouti K. The pathophysiology and consequences of red blood cell storage. Anesthesia 2015,70 (Suppl. 1). [5] Yoshida T, Blair A, D’Alessandro A, et al. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017;15(2):172-181. [6] Zimring JC. Established and theoretical factors to consider in assessing the red cell storage lesion. Blood. 2015; 125 (14): 2185-2190. [7] DʼAlessandro A, Yoshida T, Nestheide S, et al. Hypoxic storage of red blood cells improves metabolism and post-transfusion recovery. Transfusion. 2020;60(4):786-798. [8] HEMANEXT ONE® (Blood container set used to process and store CP2D/AS-3 Red Blood Cells, Leukocytes Reduced, and O2/CO2 Reduced) [US Instructions for Use]. Lexington, MA: Hemanext Inc. HEMANEXT ONE® (Blood container set used to process and store CPD/PAGGSM Red Blood Cells, Leukocytes Reduced, and O2/CO2 Reduced) [OUS Instructions for Use]. Lexington, MA: Hemanext Inc. [9] Whitley P, Wellington M, Sawyer S, et al. 2,3 Diphosphoglycerate content and oxygen affinity of Hemanext red blood cells. Poster presented at: The International Society of Blood Transfusion; June, 2018; Toronto, Canada. [10] Landry P, Ducas E, De Grandmont MJ, et al. Red blood cells anaerobic storage with Hemanext processing system. Poster presented at: The International Society of Blood Transfusion; 2018.