News

Hemanext Announces Close of Series B-3 Equity Financing Round

Hemanext Inc., a leading innovator in blood processing, storage and transfusion technology, announced the close of its Series B-3 equity financing round. The round raised $18.9 million at a post-money valuation of $172 million or $0.275 per share, with support from new investors and repeat investments from those participating in the Series B-2 capital round. The funds will position Hemanext strongly to meet specific commercial and clinical objectives in the near term ahead of its planned institutional Series C financing.

Advancing a New Standard in Red Blood Cell Therapy

The Hemanext ONE® RBC Processing and Storage system limits oxygen, the fuel for oxidative damage, providing a higher quality blood product.1,2,3 It has the potential to benefit all patients requiring transfusion for chronic conditions, such as thalassemia4, sickle cell disease (SCD)5, and myelodysplastic syndromes (MDS)6, as well as those in need of critical transfusions during acute bleeding in surgery, trauma and other medical procedures.7 Hemanext ONE has been granted marketing authorization for commercial distribution via the De Novo process by the U.S. Food & Drug Administration, is patented, and is CE marked which allows its commercial distribution within the market of the European Economic Area (EEA).

Hemanext has extensive patent coverage extending through 2039 and additional pending patent applications. Hemanext has also recently received our first US Health Care Common Procedure Coding System (HCPCS) reimbursement code from the Centers for Medicare and Medicaid Services (CMS) for hypoxic blood at $487 per unit for out-patient use—the first new code for a red blood cell product in 20 years. The Hemanext ONE System integrates seamlessly into existing transfusion medicine workflows and requires minimal clinician training or additional equipment to commence adoption.

Hospitals in select geographies have begun treating patients with hypoxic red blood cells (RBCs) produced using the Hemanext ONE system, while other leading institutions are actively validating the technology. Hemanext has:

  • Begun producing hypoxic RBCs at Vitalant, one of the largest nonprofit blood centers in the United States, for use at a large, leading U.S. hospital;
  • Initiated validation of the Hemanext ONE system at a world-renowned U.S. medical institution recognized for pioneering clinical research and patient care;
  • Initiated use of Hemanext ONE system in Greece among patients with thalassemia;
  • Commenced enrollment in a randomized controlled clinical trial in Norway for transfusion-dependent hematologic malignancy patients.

Use of Proceeds

Hemanext expects the proceeds from the B3 round to enable execution of critical commercial and clinical objectives through Q1 2026, including:

  • Expanding early access deployments across hospitals and blood centers in the U.S.;
  • Generating real-world transfusion data across a range of clinical settings;
  • Accelerating customer adoption using established reimbursement pathways;
  • Establishing recurring sales from early adopter blood banking and hospital partners.

Andrew Dunham, Chief Executive Officer of Hemanext, commented, “We are thankful for the continued trust of our existing investors and are pleased to welcome new investors who share our vision for transforming transfusion care. The capital raised gives us a clear path to generating the commercial and clinical evidence required to generate substantial revenue in 2026.”

Steve Eckert, Chairman of the Board, added, “This financing underscores strong confidence in Hemanext’s ability to achieve our mission of delivering innovations that improve the standard of care for patients who rely on transfusions by transforming RBCs through protecting their quality, functionality, and viability during storage. In addition to patient benefit, Hemanext is able to deliver a compelling value proposition to customers and investors alike. With a pure consumable model, no upfront capital investment required, simple integration into existing workflows, and materially improved reimbursement economics for providers, the company is uniquely positioned to reshape the transfusion landscape.”

About Hemanext

Hemanext is a privately held medical technology company based in Lexington, MA that is dedicated to improving the quality, safety, efficacy, and cost of transfusion therapy. The company’s research and development efforts focus on the study of hypoxically stored RBCs. The company’s aim is to significantly improve the quality of stored RBCs worldwide.

About Hemanext ONE

Hemanext ONE has been granted marketing authorization for commercial distribution via the De Novo process by the U.S. Food & Drug Administration. It is intended to process and store CP2D/AS-3 Red Blood Cells, Leukocytes Reduced (LR RBC) that have been prepared within the standard 8-hour hold time. Processing of Red Blood Cells processed with the Hemanext ONE system must be initiated within 8 hours of collection and completed within 12 hours of collection. The Red Blood Cells must be processed at room temperature (20-26°C). The Hemanext ONE system limits O2 and CO2 levels in the storage environment. Red Blood Cells Leukocytes Reduced, O2/CO2 Reduced may be stored for up to 42 days at 1-6°C. Hemanext ONE is used for volumes no greater than 350 mL of LR RBC.

In Europe, Hemanext ONE is CE marked, which allows its commercial distribution within the market of the European Economic Area (EEA).

Hemanext ONE creates hypoxic RBCs, RBCs that have been processed to reduce oxygen and carbon dioxide content of RBCs and to maintain this level throughout storage up to 42 days.3 Hypoxic RBCs have demonstrated positive impacts on multiple in vitro metrics of RBC quality in preclinical studies.8,9 Clinical studies are underway to determine the impact of hypoxic RBCs on patient outcomes and estimate potential cost savings from expected improvements in care and reductions in transfusion volumes.10

Hemanext Media Contact
Daan Kok
Head of Business Development and Strategy
Daan.kok@hemanext.com
+41 78 206 1460

 

  1. Rabcuka J, Blonski S, Meli A, et al. Metabolic reprogramming under hypoxic storage preserves faster oxygen unloading from stored red blood cells. Blood Adv. 2022;6(18):5415-5428. doi: 10.1182/bloodadvances.2022007774
  2. Reisz JA, Wither MJ et al. Oxidative modifications of glyceraldehyde 3-phosphate dehydrogenase regulate metabolic reprogramming of stored red blood cells. 2016;128(12): e32-42.
  3. HEMANEXT ONE® (Blood container set used to process and store CP2D/AS-3 Red Blood Cells, Leukocytes Reduced, and O2/CO2 Reduced) [US Instructions for Use]. Lexington, MA: Hemanext Inc.
  4. Farmakis D, Porter J, Taher A, et al. 2021 Thalassemia International Federation Guidelines for the management of transfusion-dependent thalassemia. 2022;6:8.
  5. Chou S, Alsawas M, Fasano R, et al. American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv. 2020;4:2.
  6. Germing U, Oliva E, Hiwase D, and Almeida A. Treatment of anemia in transfusion-dependent and non-transfusion-dependent lower-risk MDS: current and emerging strategies. 2019;3(6). doi: 10.1097/HS9.0000000000000314
  7. American College of Surgeons. ACS TQIP massive transfusion in trauma guidelines. ACS TQIP.2014; https://www.facs.org/media/zcjdtrd1/transfusion_guildelines.pdf.
  8. Yoshida T, Blair A, D’Alessandro A, et al. Enhancing uniformity and overall quality of red cell concentrate with anaerobic storage. Blood Transfus. 2017;15(2):172-81.
  9. Yoshida T, McMahon E, Croxon H, et al. The oxygen saturation of red blood cell concentrates: The basis for a novel index of red cell oxidative stress. Transfusion. 2022;62(1):183-193. doi: 10.1111/trf.16715.
  10. Reikvam H, Hetland G, Ezligini F, et al. Safety of hypoxic red blood cell administration in patients with transfusion-dependent hematological malignancies: An interim analysis. Transfus Apher Sci. 2023; doi: 10.1016/j.transci.2023.103755.
Previous
Next

By producing higher quality RBCs, the Hemanext ONE system has the potential to enable fewer and more effective transfusions for patients. I am truly excited by the possibility of bringing this improved red blood cell replacement therapy to populations in the U.S. that have been waiting for a transformative technology like this one.

Dr. Philip C. Spinella
Professor, Department of Surgery and Department of Critical Care Medicine at University of Pittsburgh

We value our partnership with Hemanext to enhance blood product quality and availability. Hemanext ONE has the potential to strengthen the resiliency of the blood supply, and this FDA authorization is a significant milestone to that end.

Ralph Vassallo, MD, FACP
Executive Vice President, Chief Medical and Scientific Officer of Vitalant

The Hemanext ONE system offers promise to improve the treatment landscape for patients burdened by transfusions and could be an essential step towards performing fewer and better transfusions. Having long championed Hemanext’s transformative initiatives, I eagerly anticipate witnessing the positive influence, right here in the United States, on the advancement of transfusion therapy quality.

Paul M. Ness, MD
Former Director, Division of Transfusion Medicine at Johns Hopkins University and board member of Hemanext

By deoxygenating red cells and maintaining them in their hypoxic state throughout storage, the resulting red cells experience less oxidative stress and oxidative damage, have improved metabolism, and are also more deformable leading to improved micro vascular profusion and less hemolysis.

Dr. Steven Spitalnik, MD
Co-Director of the Laboratory of Transfusion Biology, Colombia University

The preclinical data by Williams et al. show anaerobically stored RBCs achieve multiple clinically important functional resuscitation goals, with a smaller volume of fluid and the FDA benchmark of 24-hour RBC recovery. I look forward to the clinical trials in bleeding patients.

John Holcomb, MD, FACS
University of Alabama at Birmingham

I have had several patients who have received Hemanext hypoxic blood, and several of the patients have personally said thanks for having been given the opportunity and also that they have felt better after transfusion with hypoxic blood compared to conventional transfusion. One must of course be careful not to attach too much importance to such observations, but I would still like to mention that there has been a remarkable tendency towards this.

Håkon Reikvam, MD, PhD
Professor, Department of Clinical Science, University of Bergen, Norway

CONTACT US  |  TERMS OF USE

PRIVACY & COOKIES POLICY

This website may contain information on products or uses of those products that are not authorized in all countries or regions. Hemanext ONE has been granted marketing authorization for commercial distribution via the De Novo process by the U.S. Food & Drug Administration. In Europe Hemanext ONE is CE marked which allows the medical device to be placed in the market in the EEA. Illustrations are artist’s representations only and should not be considered as engineering drawings or photographs. Hemanext, Hemanext ONE, and the logos are registered trademarks of Hemanext, Inc. © 2026 Hemanext, Inc. All rights reserved.

Contact Us